Endocrine Abstracts

Aim: Stimulated thyroglobulin (sTg), measured at radioiodine remnant-ablation (RRA) in patients with differentiated thyroid cancer(DTC), is an important predictive factor of persistent disease. However, Tg produced by normal thyroid cells may also contribute to the sTg value.We aimed to study the relationship between sTg-level in RRA and the thyroid remnant size (TRs), using post-therapy whole-body scan (131I-ptWBS), at different TSH stimulation method.<...

: Nonfunctioning pituitary adenomas (NPA) are prevalent neoplams from pituitary. The best treatment is the surgical approach but residual tumours are common. For residual tumours the options are radiotherapy (RT) and re-surgery. There are no significant studies testing drugs in NPA. Due to the fact that these tumors express dopamine D2 receptors, dopamine agonists that may be useful in patients with NPA.Methods: We selected 145 patients with residual tum...

Background: The review of the Bethesda System Classification has brought some challenge to the clinical role of category III lesions. Repeating fine-needle aspiration (FNA) is time-consuming, painful, brings additional cost and sometimes does not change the clinical decision. Our aim was to prove if there is true benefit in repeating FNA.Methods: Retrospective review of 4549 thyroid FNAs between January 2012 and June 2015, from which 671 classified as AU...

Introduction: Hypocalcaemia is a potential post-thyroidectomy complication. Patients with previous Roux-en-Y Gastric Bypass (RYGBP) are at increased risk of symptomatic hypocalcaemia refractory to treatment. This complication is rare and there is not consensus on how to act.Clinic case: Female with 34 years old, with a history of Obesity (BMI 45.7 kg/m2), submitted to RYGBP in 2013, with a total loss of 47 kg (current BMI 27.3 kg/m2...

Introduction: Metabolic syndrome (MS) is related with progressive decrease of renal function. Although hypertension has a major role on this relationship, it is not clear how its behavior is related to decreased renal function.Objective: To study how blood pressure (BP) measured by 24-hour ambulatory BP is related to renal function in patients with and without MS.Methods: We designed a cross-sectional study of consecutive individua...

Introduction: The hyperthyroidism is a risk factor for tachyarrhythmia and dilated cardiomyopathy. Amiodarone is an effective antiarrhythmic medication, however if coexisting thyroid pathology complicates the treatment of thyroid dysfunction. It presents a case of Graves’ disease (GD) of long evolution, which illustrates the complexity of these associations. Clinical case: man, 44 years old, smoker, history of acute myocardial infarction and GD diagnosed at age 28. Has ma...

Introduction: Clinical inertia applied to type2 Diabetes Mellitus (T2DM) treatment, is defined as a lack of treatment’s intensification of patients who are not in HbA1c target. Clinical inertia leads to a postponement of new therapeutic introduction, with all complications associated with a poor metabolic control. In Portugal there are only studies that show good or poor metabolic control but do not mention clinician’s attitude towards these values. Recently publishe...

Introduction: The SGLT-2 inhibitors (InibSGLT2) are the newest class of non-insulin antidiabetic drugs (ANI) for type 2 diabetes mellitus (T2DM) treatment. Currently is only available in Portugal, dapagliflozin. This pharmacological class have shown benefits in metabolic control (reduction of 0.5–0.8% HbA1c) and in weight loss (1–3 kg).Objective: Evaluate the impact of InibSGLT2 in patients with T2DM followed in a Diabetes department.<p cla...

Introduction: In our practice we’ve been following some oncologic survivors patients with low-low/normal levels of testosterone who are asymptomatic. Aims: to determine the levels of total (TT) and free testosterones (FT) and dihydrotestosterone (DHT) in healthy men, in order to find the reference intervals (RI) adjusted to our population and compare them with those provided by the kit-producers (KP).Methods: We collected blood samples from 125 heal...

Introduction: Bariatric surgery (BS) is an effective method to weight loss, however, some patients experience persistence of physical inactivity or even weight gain over the years. Furthermore, It is not clear if some surgical techniques, mainly those with disabsortive components, could be involved in the low physical performance through interfering with nutritional status This study aimed to evaluate physical function (PF), quality of life (QOL) and energy expenditure (EE) du...